ABSTRACT
Background: After spinal anesthesia, patients undergoing cesarean section are more likely to develop hemodynamic changes. The baricity of local anesthetic has an important role on spinal blockade effects. The aim of this study was to compare the isobar and hyperbaric bupivacaine 0.5% plus fentanyl on maternal hemodynamics after spinal anesthesia for C/S
Methods: In this double-blind study, 84 healthy pregnant women undergoing C/S using bupivacaine 0.5% isobar [study group, n=42] or hyperbaric [control group, n=42] for spinal anesthesia were scheduled. The study was conducted from 21 April 2014 to 21 November 2014 at Al-Zahra Hospital, Tabriz, Iran. Parameters such as maternal hemodynamics, block characteristics, side effects, and neonatal Apgar scores were recorded. Data were analyzed using the SPSS software by performing chi-square test, Fisher's exact test, one-way ANOVA, Mann-Whitney U-test, and student's t test
Results: The incidence of hypotension in the isobar group was lower than the hyperbaric group, although it was not statistically significant [40.47% vs. 61.9%, P=0.08]. The duration of hypotension was shorter in the study group [1.6 +/- 7.8 min vs. 7.4 +/- 12.5 min, P=0.004]. The dose of ephedrine was lower in the study group [2.4 +/- 6.6 mg vs. 5.3 +/- 10.7 mg, P=0.006]. The main maternal side effect is sustained hypotension that was seen in 0 patients of the isobar and 7 [16.66%] of hyperbaric groups [P=0.006]. None of the neonates had Apgar score
Conclusion: Isobaric bupivacaine is associated with more hemodynamic stability and shorter sensory and motor blockade in mothers under spinal anesthesia for C/S
ABSTRACT
To investigate the serum concentrations of copper [Cu], zinc [Zn] and copper/zinc ratio [Cu/Zn] in patients with ovarian cancer and benign ovarian lesions. The study included 50 patients, with ovarian cancer [malignant group] and 50 patients with benign ovarian lesions [benign group]. After overnight fasting, blood samples were collected. The concentrations of Cu and Zn were measured by Atomic Absorption Spectrophotometry [AAS]. There was a significant increase in mean serum levels of Cu [p=0.0001] and the ratio of Cu/Zn [p=0.003] in ovarian cancer patients. However, there was no significant difference in the mean serum levels of Zn between two groups [p=0.71]. The study showed that serum copper and copper/zinc ratio were significantly higher in ovarian cancer patients when compared to the patients with benign ovarian lesions. It seems that determination of serum copper and copper/zinc ratio may be used as a test for diagnosing of ovarian cancer